摘要
目的探讨女性系统性红斑狼疮(SLE)患者血清肿瘤标志物甲胎蛋白(AFP)、癌胚抗原(CEA)、肿瘤抗原CA125和CA19-9含量变化及临床意义。方法用微粒子酶免疫分析方法测定56例女性SLE患者血清中AFP、CEA、CA125和CA19-9水平,并与健康对照组进行比较。结果女性SLE患者血清AFP、CA125和CA19-9含量显著高于健康对照组,差异有统计学意义(P<0.05);CEA水平与健康对照组比较差异无统计学意义;SLE患者CA125阳性率显著升高。结论SLE患者某些血清肿瘤标志物含量较健康对照组增高,可能与器官受累有关。
Objective To investigate the levels of tumor markers AFP,CEA,CA125 and CA19-9 in serum of female patients with systemic lupus erythematosus (SLE) and to explore their clinical value. Methods The tumor markers AFP,CEA,CA125 and CA19-9 in serum of the 56 female SLE patients were detected by means of MEIA, and compared with normal controls. Results The mean absolute serum levels of AFP,CA125 and CA19-9 was significantly higher in female SLE(P〈0.05). There were significantly more SLE patients showing abnormally high levels of CA125. Conclusion The concentration of some tumor-associated antigens (TAAs) may be elevated in the serum of patients with SLE in comparison with healthy subjects. The production of some TAAs may correlate with organ involvement in SLE.
出处
《检验医学与临床》
CAS
2009年第16期1351-1351,1353,共2页
Laboratory Medicine and Clinic
关键词
红斑狼疮
系统性
甲胎蛋白
癌胚抗原
CA-125抗原
免疫酶技术
lupus erythematosus,systemic
alpha-fetoproteins
carcinoembryonic antigen
CA-125 antigen
immunoenzyme techniques