摘要
目的探讨全自动电泳分析系统筛查地中海贫血(简称地贫)的应用价值。方法选择2008年1~12月已被基因诊断确诊的138例地贫患者和69例非地贫患者,对其血红蛋白电泳结果进行回顾性分析。结果与基因分析法相比,全自动电泳分析系统筛查α地贫的敏感性为95.0%,特异性为91.3%,诊断准确性为93.3%,阳性预测值95.0%,阴性预测值94.0%;筛查β地贫的敏感性为98.3%,特异性为95.7%,诊断准确性为96.9%,阳性预测值95.0%,阴性预测值98.5%。结论全自动电泳分析系统具有较高的特异性和较好的敏感性,是一种筛查地贫的理想方法。
Objective To study the value of hemoglobin electrophoresis for diagnostic of thalassemia. Methods 138 samples of thalassemia patients and 69 samples of non thalassemia controls verified by genetic analysis were detected by hemoglobin electrophoresis during January to December of 2008. Results Compared with genetic analysis method,the sensitivity, specificity ,accuracy,positive prediction and negative prediction of hemoglobin electrophoresis for a model thalassemia were 95.0% ,91.3% ,93.3% ,95.0% and 94.0% respectively,and for βmodel thalassemia were 98.3% ,95.7% ,96.9% ,95.0% and 98.5% respectively. Conclusion Hemoglobin electrophoresis is high specific and sensitive for diagnose of thalassemia,and it is a good method in detecting thalassemia.
出处
《检验医学与临床》
CAS
2009年第16期1352-1353,共2页
Laboratory Medicine and Clinic
关键词
地中海贫血
血蛋白电泳
基因型
普查
电泳
琼脂凝胶
thalassemia
blood protein electrophoresis
gentype
mass screening
electrophoresis,agar gel