皮质抑素的生物学效应研究进展

Progress in Biological Effects of Cortistatin

皮质抑素是1996年在哺乳动物大脑皮质中发现的与生长抑素结构有高度同源性的活性多肽,广泛分布于人体的组织器官中,包括大脑皮质、冠状动脉、胃、肾、睾丸、视网膜、白细胞和免疫系统等。研究表明,皮质抑素能够与生长抑素受体、生长激素促分泌物受体1a及Mas相关基因2受体结合发挥多种生物学作用,包括调节学习与记忆过程,诱导睡眠,抑制炎症,调节内分泌代谢及发挥心血管效应,是调节机体自稳态平衡的重要因素。

Cortistatin, cloned from cerebral cortex in mammal in 1996, is a sort of polypeptide with multiple biological activities and shares high structural homology with somatostatin. It is widely distributed in tissues and organs of human body, such as brain, coronary artery, stomach, kidney, testis, leukocyte and immunological system. A growing evidence indicates that cortistatin exerts many kinds of biological effects including modulating the process of study and memory, inducing sleep, inhibiting inflammation and regulating endocrine metabolism and homeostasis of cardiovascular system. And these effects are me- diated by binding somatostatin receptors, grow hormone secretagogous reeeptor-la and Mas-related geneX2 receptor. Cortistatin is considered an important factor regulating the balance of body homeostasis.