摘要
目的观察氟比洛芬酯对于阻塞性睡眠呼吸暂停低通气综合征手术患者的超前镇痛作用。方法将40例ASAⅠ或Ⅱ级择期行悬雍垂腭咽成形术患者随机分为两组各20例,均采取气管内插管全麻。治疗组术前30min静脉注射1mg.kg-1氟比洛芬酯;对照组术毕时静脉注射1mg.kg-1氟比洛芬酯。术后用视觉模拟评分法(VAS)评估患者术后1,3,6和24h疼痛感觉程度,观察与氟比洛芬酯有关的不良反应。结果术后1h治疗组VAS显著低于对照组(P<0.01),术后3,6hVAS低于对照组(均P<0.05),而术后24h两组间差异无显著性。结论氟比洛芬酯术前静脉应用有良好的超前镇痛作用,不良反应少。
Objective To assess the effects of preemptive analgesia with flurbiprofen on the postoperative pain in patients undergone uvulopalatopharyngoplasty surgery. Methods 40 cases of patients scheduled for selective uvulopalatopharyngoplasty surgery were randomly divided into two groups, and they were under general anesthesia by tracheal intubation. Patients in group A received flurbiprofen 1 mg · kg^-1 intravenously thirty minutes before operation . those in group B received flurbiprofen 1 mg · kg^-1 after operation. The analgesia effects after operation were assessed by visual analogue scale （VAS） at 1,3,6, 24 hours after operation, and side effects were assessed as well. Results The VAS of group A was significant lower than that of group B at 1 hour after operation （P 〈0.01 ） , at 3 and 6 hours after operation （P 〈0.05） , but no obvious difference was found between two groups at 24 hour. Condusion Preemptive analgesia with flurbiprofen 1 mg · kg^-1 could provide satisfactory pain relief without obvious side effects.
出处
《医药导报》
CAS
2009年第8期1033-1035,共3页
Herald of Medicine
