2型糖尿病患者大血管病变相关因素分析

The correlation risk factors of macroangiopathy in type 2 diabetes

目的探讨2型糖尿病患者外源性血浆凝血因子Ⅶ(FVII)和内源性血浆凝血因子Ⅷ(FVIII)水平与糖尿病大血管病变(DMAP)的关系。方法2型糖尿病患者依大血管病变程度进行临床分组:重度DMAP组(sDMAP)、轻度DMAP组(mDMAP)、无DMAP组(Non-DMAP),并设健康对照组,对各组FVII、FVIII、纤维蛋白(Fib)、三酰甘油(TG)水平及吸烟人数比例等指标进行比较。结果2型糖尿病患者FVII、FVIII.Fib、TG水平及吸烟人数比例高于健康对照组(P<0.01,P<0.05);sDMAP组及mDMAP组均高于Non-DMAP组(P<0.01,P<0.05);sDMAP组高于mDMAP组(P<0.05)。多因素Logistic回归分析表明,FVII、FVIII、Fib、TG和吸烟与DMAP病变程度呈正相关(P<0.05)。结论FVII、FVIII、Fib、TG水平及吸烟是DMAP的独立危险因素。

Objective To explore the relationship between the level of ectogenesis plasma coagulation factor VII （ FVII ） and endogenous plasma coagulation factor VIII （FVIII） with diabetic macroangiopathy （DMAP）. Methods According to the degree of DMAP,the type 2 diabetes patients were divided into severity DMAP （sDMAP） group, mild DMAP（mDMAP） group and non DMAP group. The indexes, which included FVII, FVIII, Fib,TG and smoker percentage, were detected and compared with normal control group. Results The levels of FVII, FVIII,Fib,TG and smoker percentage in type 2 diabetes were significantly higher than those in normal controls（ P 〈 0.01 or P 〈 0.05 ）. Furthermore, the indexes were higher in sDMAP and mDMAP group than those in non DMAP group （ P 〈 0.01 , P 〈 0.05） ,it＇ s higher in sDMAP group than in mDMAP group （ P 〈 0.05 ）. Multiple factors logistic regression analysis showed that the level of FVII, FVIII,Fib,TG and smoking had positive correlation with the degree of DMAP （P 〈 0.05）. Conclusion It validated that the level of FVII,FVIII,Fib, TG and smoking was independent risk factors in DMAP.