丙戊酸钠治疗癫痫持续状态的疗效及安全性

Safety and therapeutic effects of sodium valproate on epileptic state

目的：评估丙戊酸钠（VPA）快速静滴控制癫痫持续状态（SE）的有效性及安全性。方法：60例SE患者随机分为治疗组和对照组各30例，对照组安定首剂10mg静脉注射，随后以（1．5～2．0）μg／（kg·min）的速度微泵持续静注安定；治疗组首剂给丙戊酸钠注射剂（10～15）mg／kg，在3—5min内静脉注射，而后以（0．5～1）mg／（kg·h）持续静脉滴注，根据病情调整滴注速度。结果：治疗组总有效率83．3％，对照组为66．7％，治疗组的有效率高于对照组（P〈0．05）。治疗组癫痫完全控制时间（29．01±10．84）s明显短于对照组癫痫完全控制时间[（34．93±10．54）s]（P〈0．05）。结论：快速静脉使用VPA治疗癫痫持续状态起效快，作用强，安全有效。

Objective： To assess effects and safety of rapid intravenously guttae of sodium valproate on epileptic state （SE）. Methods ：60 cases of SE patients were randomly divided into treatment group and control group（ n = 30）. In control group, diazepam was firstly given by intravenous injection at 10 mg, and then it was given continuously by intravenous drip at（ 1.5 -2.0 ）μg/（ kg · min）. In treatment group, intravenous injection of sodium valproate was firstly administered at （ 10 - 15 ） mg/kg within 3 - 5 minutes, and then it was administered continuously by intravenously guttae at （0.5 -1.0 ） mg/（ kg · h） which was adjusted according to the patients＇ state. Results：The overall efficiency of treatment group was 83.3 % and was significantly higher than that of control group （ 66.7 % ） （ P 〈 0.05 ）. The total control time of treatment group was （29.01 ± 10.84） seconds and was significantly shorter than that of control group [ （ 34. 93 ±10. 54 ） seconds ] （ P 〈 0. 05 ）. Conclusion： Rapid intravenously guttae of sodium valproate are safe and has strong and quick efficacy on SE.