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丙戊酸钠治疗癫痫持续状态的疗效及安全性 被引量:16

Safety and therapeutic effects of sodium valproate on epileptic state
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摘要 目的:评估丙戊酸钠(VPA)快速静滴控制癫痫持续状态(SE)的有效性及安全性。方法:60例SE患者随机分为治疗组和对照组各30例,对照组安定首剂10mg静脉注射,随后以(1.5~2.0)μg/(kg·min)的速度微泵持续静注安定;治疗组首剂给丙戊酸钠注射剂(10~15)mg/kg,在3—5min内静脉注射,而后以(0.5~1)mg/(kg·h)持续静脉滴注,根据病情调整滴注速度。结果:治疗组总有效率83.3%,对照组为66.7%,治疗组的有效率高于对照组(P〈0.05)。治疗组癫痫完全控制时间(29.01±10.84)s明显短于对照组癫痫完全控制时间[(34.93±10.54)s](P〈0.05)。结论:快速静脉使用VPA治疗癫痫持续状态起效快,作用强,安全有效。 Objective: To assess effects and safety of rapid intravenously guttae of sodium valproate on epileptic state (SE). Methods :60 cases of SE patients were randomly divided into treatment group and control group( n = 30). In control group, diazepam was firstly given by intravenous injection at 10 mg, and then it was given continuously by intravenous drip at( 1.5 -2.0 )μg/( kg · min). In treatment group, intravenous injection of sodium valproate was firstly administered at ( 10 - 15 ) mg/kg within 3 - 5 minutes, and then it was administered continuously by intravenously guttae at (0.5 -1.0 ) mg/( kg · h) which was adjusted according to the patients' state. Results:The overall efficiency of treatment group was 83.3 % and was significantly higher than that of control group ( 66.7 % ) ( P 〈 0.05 ). The total control time of treatment group was (29.01 ± 10.84) seconds and was significantly shorter than that of control group [ ( 34. 93 ±10. 54 ) seconds ] ( P 〈 0. 05 ). Conclusion: Rapid intravenously guttae of sodium valproate are safe and has strong and quick efficacy on SE.
作者 杨建明
出处 《西南国防医药》 CAS 2009年第8期782-783,共2页 Medical Journal of National Defending Forces in Southwest China
关键词 丙戊酸钠 癫痫持续状态 sodium valproate epileptic state
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