我院158例药品不良反应报告分析

Analysis of 158 ADR Reports in Our Hospital

目的:了解我院药品不良反应(ADR)发生情况,促进临床合理用药。方法:采用回顾性分类统计方法,对158例报告就ADR分布与年龄、给药途径、药物分类、累及系统或器官、ADR严重程度方面进行统计分析。结果:在158例ADR报告中涉及71个药物品种,由抗菌药物导致的ADR最多,占总数的31.0%;其中65岁以上老年患者最多,占总例数的19.0%;以静脉滴注(72.8%)方式为主;临床表现以皮肤及附件损伤最常见,占总例数的47.5%。结论:临床应重视ADR报告和监测工作,避免或减少ADR发生。

Objective： To review the occurrence of adverse drug reactions （ADRs） in our hospital and promote rational drug use in clinic. Methods： 158 ADR cases were retrospectively analyzed in respect of the ages of patients, routes of administration, categories of drugs, systems or organs involved in ADRs and the serious degree of ADRs. Results： 71 Categories of drugs were involved in the 158 ADR cases, and anti-infective agents ranked the first, accounting for 31.0%. The patients whose ages were above 65 occupied mostly, accounting for 19.0%. The intravenous drip was the main route of administration, accounting for 72.8%. The lesions of skin and appendants were the main clinical manifestations, accounting for 47.5%. Conclusion： It should be paid more attention to the ADR report and monitoring in clinic in order to avoid or decrease the occurrence of ADRs.