低频重复经颅磁刺激治疗精神分裂症慢性幻听的疗效及随访研究

The effect of slow repetitive transcranial magnetic stimulation in the treatment of chronic auditory hallucinations in schizophrenia and the follow-up study.

目的研究低频重复经颅磁刺激(rTMS)对精神分裂症难治性慢性幻听症状的疗效。方法将46例精神分裂症伴慢性幻听患者随机分为研究组(23例)和对照组(23例)。研究组在原有抗精神病药物种类及剂量不变的同时给予经左侧颞顶叶的2周共10次低频(1Hz)rTMS刺激,对照组采用假rTMS刺激。治疗前后对两组分别进行AHRS听幻觉量表及临床疗效总评量表(CGI)评定幻听症状的变化,并对治疗有效者于3个月后随访。结果研究组治疗前、后AHRS评分分别为(8.1±2.5)和(3.5±1.5);对照组为(7.8±2.6)和(6.5±2.1),研究组疗效明显优于对照组(F=20.3,P<0.05)。所有患者均完成试验,未见有严重的副反应出现。结论低频rTMS治疗精神分裂症难治性慢性幻听症状,疗效肯定且安全性好。

Objective To explore the effects of slow repetitive transcranial magnetic stimulation （rTMS） for treating chronic auditory hallucinations in schizophrenia. Methods Forty-six schizophrenic patients with chronic auditory hallucinations were randomly divided to active slow rTMS group （23 cases） and sham rTMS group （23 cases）. All patients received antipsychotic drugs without change throughout the study period. The effects were assessed by Auditory Hallucination Rating Scale （AHRS） and Clinical Global Impression （CGI）. Results The scores of AHRS in rTMS group before and after treatment were（8.1±2.5） and （3.5±1.5）, those of control group were （7.8±2.6） and （6.5±2.1）. The efficacy of the rTMS group was significantly superior to that of the control group （F=20.3,P〈0.05）. All patients completed the trial, and no serious side effects were found. Conclusion Slow rTMS is effective for treating chronic auditory hallucinations in schizophrenia.