精神分裂症患者迟发性运动障碍临床特征分析

Analysis of the clinical features in schizophrenic patients with tardive dyskinesia

目的描述迟发性运动障碍(TD)患者异常不自主运动的状况和特征,分析TD发生可能的相关因素。方法共入组TD患者140例,采用阳性和阴性症状量表(PANSS)评定精神症状,采用Simpson迟发性运动障碍专用量表、异常不自主运动评定量表(AIMS)系统评估TD的严重程度及发生频率。结果在140例TD患者的8类不同部位的异常运动中,上、下肢体和舌部的舞蹈样动作发生率最高(均大于80%),其中上肢的异常不自主运动的发生比例高达90%,脸部、颌异常运动的发生率只有30%左右。结论在TD患者中,四肢末端和舌部的异常不自主运动最为频发,典型的口-舌-颊三联征并不常见。

Objective To investigate the clinical features and frequencies of abnormal involuntary movement symptoms in schizophrenic patients with Tardive Dyskinesia（TD）. Methods To evaluate severity and frequency of dyskinesia movement in schizophrenic patients with TD （n= 140） by the Abnormal Involuntary Movement Scale （AIMS） and the Simpson-Angus Extrapyramidal Sign Scale,to assess the psychophathology with Positive and Negative Symptom Scale （PANSS）. Results Among 140 patients with TD recruited in the present study, the abnormal involuntary movements of extremities （upper limb： 92.6% ; lower limb：80.0%） and tongue （89. 2 %） were the most significant manifestations in the AIMS, oro-buccal-lingual-facial （orofacial） dyskinesia was not a common manifestation （the rate was 30%）. Conclusion Abnormal involuntary movements in the extremities and tongue in patients with TD are the most manifestation. On the contrary, oro-buccal-lingual-facial （orofacial） dyskinesia is not common clinical features.