长期胰岛素治疗对2型糖尿病患者C反应蛋白影响的研究

Study of the effect of long-time insulin treatment on CRP of type 2 diabetic subjects

目的研究长期胰岛素(疗程≥1年)治疗对2型糖尿病患者体内的炎症因子CRP的影响。方法入选胰岛素治疗疗程≥1年的2型糖尿病患者,分析胰岛素治疗后的体重变化与C反应蛋白、体重指数、腰臀比的关系。结果与体重无变化组相比,体重增加≥5kg组CRP水平显著升高(P<0.01)、体重增加0～5kg组CRP水平无明显升高。与体重无变化组相比,体重增加≥5kg组BMI显著增加(P<0.05),体重增加0～5kg组BMI无显著增加。与体重无变化组相比,体重增加≥5kg组WHR显著增加(P<0.05),体重增加0～5kg组WHR也显著增加(P<0.05)。结论2型糖尿病患者长期胰岛素治疗(疗程≥1年)所致的体重增加可能导致体内炎症因子CRP、BMI及腰臀比明显升高。

[Objective] To observe the effect of long-time insulin treatment on CRP of type 2 diabetic subjects. [Methods] 68 patients with insulin therapy duration over 1 year and were anti-GAD negative with complete data, including background information of each individual, HbAlc, plasma glucose and insulin, lipid profile and blood pressure. Analyse association of the change of weight with CRP, BMI, WHR and HOMA-IR. [Results] Compared with no weight change group： CRP of weight gain ≥ 5 kg group was higher （P 〈0.01）, CRP of weight gain 0-5 kg group was mild higher （P 〉0.05）. BMI of weight gains〉5 kg group was higher （P 〈0.01）, BMI of weight gain 0~5 kg group was mild higher （P 〉0.05）. WHR of weight gain I〉 5 kg group was higher （P 〈0.05）, WHR of weight gain 0-5 kg group was higher （P 〈0.05）. [ Conclusion] The accompanied weight gain of long-term insulin treatment （≥ 1 year） of type 2 diabetic subjects may increase CRP, BMI and WHR.