摘要
p16是近年发现肿瘤抑制基因,其高表达与宫颈病变关系密切,且与人乳头瘤病毒(HPV)感染呈正相关。在宫颈脱落细胞中P16蛋白的表达与HC-2检测一样能够增加细胞学诊断的敏感性,且p16较HC-2检测更能够区分ASCUS细胞中是否存在病变。在一定程度上可以代替HC-2检测,提高子宫颈鳞癌的早期诊断率,从而降低传统宫颈癌筛查法的假阳性率和假阴性率,提高筛查的灵敏度和特异度,值得推广。
p 16 is one of the tumour anti-oncogenesis. The high expression of p 16 and HPV (human papillomavirus) have direct correlation. The expression of p16 in Papanicolaou smears as HC-2 test could increase the sensitivity of cytological diagnosis, and may serve as a useful biomarker in ASCUS-containing smear diagnoses. On the whole, p16 could improve pristine diagnosis rate of squamous cell carcinoma, and have important significance in the specificity and sensitivity of cervix cancer screening.
出处
《国际妇产科学杂志》
CAS
2009年第4期272-274,282,共4页
Journal of International Obstetrics and Gynecology
关键词
P16
宫颈癌
宫颈上皮内瘤样病变
人乳头瘤病毒
液基细胞学检查
p16
Cervical cancer
, Cervical intraepithelial neoplasia
Human papilloma virus
Liquidbased cervical smears