氟取代在天然产物结构修饰中的最新进展

Recent progress of fluorine substitution in the structural modification of natural products

对天然产物的分子结构进行合理的修饰是增强天然产物的生物活性和类药性的有效方法,氟原子的引入能够赋予有机分子独特而有利的生理化学性质,从而改变其药理学性质。该文介绍几种有代表性的氟取代的天然产物及其药用价值。

The rational modification of natural products in an effort to alter their biochemical capacity and drug-likeness is a common technique. Fluorine substitution imparts unique and advantageous physio-chemical properties that can be shrewdly employed to constructively alter pharmacological agents. This overview discusses several of the most relevant fluorinated natural products and their medicinal value.