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Wnt信号通路在肾病发病中的作用 被引量：2

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摘要 Wnt信号通路早先发现时被认为其主要与细胞增殖旺盛的胚胎发育和肿瘤发生相关。目前研究发现，在肾脏发育及急性肾小管损伤中，Wnt信号通路发挥了积极的促进其发育和修复损伤的作用；但却又是多囊肾病及肾癌的关键发病机制之一。由此表明，肾脏的发育、形态以及功能的维持均有赖于Wnt信号通路正常“开启”和及时“关闭”。本文就近年来Wnt信号通路在肾脏疾病发生、发展中的作用作一综述。
作者 刘沫言 梅长林
机构地区 第二军医大学长征医院肾内科解放军肾脏病研究所
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2009年第8期655-658,共4页 Chinese Journal of Nephrology
关键词 WNT信号通路 发病机制 多囊肾病 急性肾小管损伤 胚胎发育 肾脏发育 肿瘤发生 细胞增殖
分类号 R692 [医药卫生—泌尿科学]
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参考文献32

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二级参考文献60

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共引文献10

同被引文献37

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  • 3康迅雷,易静.低氧诱导因子-1α的翻译后化学修饰及其对活性的调控作用[J].生命科学,2006,18(4):385-390. 被引量：2
  • 4张曙光,刘芝华,张林.凋亡抑制基因XIAP在肿瘤治疗中的研究进展[J].世界华人消化杂志,2006,14(26):2626-2631. 被引量：6
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中华肾脏病杂志
2009年 第8期

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