噬菌体展示技术及其在感染性疾病中的应用

Phage Display and Its Application to Infectious Diseases

感染性疾病是病原体与宿主相互作用的结果。了解病原体与宿主相互作用的分子基础,对于感染性疾病的预防和控制尤为重要。噬菌体展示技术不仅广泛应用于抗原表位作图和抗体工程技术,而且还可用于研究蛋白质与配体的相互作用,以揭示感染过程中蛋白与配体的相互作用机制。本文仅就噬菌体展示技术及其在感染性疾病中的应用作一综述。

Microbial infections are dependent on the panoply of interactions between pathogen and host. Identifying the molecular basis of such interactions is necessary to understand and control infection. Phage display is not only widely used in antigenic epitope mapping, antibody engineering, but also to identify peptide-ligand and protein-ligand interactions that are of importance in infection. Phage display and its application to infectious diseases are reviewed in this paper.