阿维A联合NB-UVB治疗泛发性斑块状银屑病疗效观察

Observation of the Efficacy of Acitretin Combined with NB-UVB on Generalized Psoriasis Plaque

目的探讨阿维A联合窄谱中波紫外线(NB-UVB)照射治疗泛发性斑块状银屑病的疗效。方法将入选的65例患者分为两组,治疗组35例,予口服阿维A胶囊,同时行NB-UVB全身照射;对照组30例,仅予NB-UVB全身照射。两组疗程均为10周。结果治疗组有效率为91.43%,对照组为66.67%,两组有效率比较,差异有统计学意义(P<0.5),两组复发率比较,差异无统计学意义(P>0.05)。结论阿维A联合NB-UVB照射治疗泛发性重度斑块状银屑病疗效好,不良反应少。

Objective To investigate the efficacy of acitretin combined with narrow-band ultravioletB （NB-UVB） in the treatment of patients with psoriasis plaque. Methods A total of 65 patients with psoriasis plaque was randomly divided into treatment group（35 cases） and control group（30 cases）. Treatment group was treated with acitretin and NB-UVB,while control group was treated with NB-UVB only. The two groups were both treated for 10 weeks. Results The effective rate was 91.43% in treated group, and 66.67% in control group. There was significant difference between two groups （P 〈 O. 05 ）. The recurrence rate of the two groups has no significant difference（P 〈 0.05）. Conclusion Radiation of acitretin combined with NB-UVB is safe and can improve the therapy efficacy significantly for patients with generalized psoriasis plaque.