益肾活血饮配合亚砷酸治疗多发性骨髓瘤骨病的观察

The Effect of Yi-Shen-Huo-Xue Yin(YSHXY)Plus Arsenic Trioxide on Multiple Myeloma Lytic Bone Disease

目的:观察益肾活血饮对骨髓瘤骨病骨代谢的影响。方法:30例患者随机分为治疗组和对照组,治疗组以益肾活血饮配合亚砷酸治疗,对照组仅以亚砷酸治疗,6个疗程后比较疗效。主要指标有:骨痛的评分、白蛋白校正后血钙浓度、尿I型胶原氨基末端肽(NTx)/尿肌酐(Cr)、血清骨特异性的碱性磷酸酶(bALP)、血清核因子kappaB受体激活剂(RANK)的配体(RANK-L)和护骨素(OPG)及RANKL/OPG比值等。结果:治疗组在骨痛的评分、白蛋白校正后血钙浓度、尿I型胶原氨基末端肽(NTx)/尿肌酐(Cr)、血清骨特异性的碱性磷酸酶(bALP)、血清核因子kappaB受体激活剂(RANK)的配体(RANK-L)和护骨素(OPG)及RANKL/OPG比值等方面均有改善,而对照组仅在骨痛的评分方面有改善。结论:益肾活血饮是治疗骨髓瘤骨病的有效方剂。

Objective ： Observe the effect of Yi-Shen-Huo-Xue Yin（YSHXY） on the bone matabolism of multiple myeloma bone disease. Methods ：30 patients were randomized to recieve YSHXY plus Arsenic Trioxide（ AT）, or only AT for 6 months respectively. Bone pain were evaluated by VAS count ,and bone matabosism were tested by serum albumin -adjusted calcium, urinary N-telopeptide/creatinine（ NTx/Cr）, serum bone-specific alkaline phosphatase（ bALP）, sermn receptor activator of NF-kappa B ligand （RANKL） ,serum osteoprotegefin（OPG） ,and RANKL/OPG. Results：YSHXY plus AT improved bone pain and bone matabolism indices （NTx/Cr, bALP, RANKL, OPG, RANKL/OPG）, while AT only decreased bone pain and serum RANKL level. YSHXY plus AT was more effective than AT on Multiple Myeloma Lytic Bone Disease. Conclusion：YSHXY is an efficient decoction for multiple myeloma bone disease.