摘要
采用丙三醇缩水甘油醚(GPE)和碳化二亚胺(EDC)对脱细胞真皮基质(pADM)分别进行交联改性,通过对交联后材料EC(GPE)-pADM、EDC-pADM的交联效率、XPS分析、KM鼠经口急毒、浸提液细胞毒性的表征和比较,探寻改性方法与材料性能之间的基本关系。研究结果表明,EDC比EC具有更高的交联效率;EC-pADM的亲水性能比EDC-pADM更好;EDC-pADM浸提液对KM鼠表现出一定经口毒性,而EC-pADM的毒性相对较低;两者浸出液细胞毒性检测均合格。综合而言,EC-pADM的性能优于EDC-pADM。
Porcine acellular dermal matrix （pADM） was crosslinked by epoxy compound （glycerol polyglycidyl ether）and carbodiimide （EDC） respectively. The properties of pADM, EDC-pADM, EC（GPE）-pADM were mensurated, such as efficiency of crosslinking, XPS, acute toxicity and cytotoxicity. It was showed that glycerol polyglycidyl ether （GPE） was less effective than EDC, hydrophilic performance of EC-pADM was better than EDC-pADM. The acute toxicity of extraction of EC-pADM on mice by mouth did not appeared whereas EC- pADM did. The cytotoxicity of extraction botainted from them respectively weren＇t observed in L-929 fibroblasts cultivated experiment. It was concluded that the properties of EC-pADM was better than EDC-pADM.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2009年第8期1352-1354,1358,共4页
Journal of Functional Materials
基金
成都市科技攻关计划资助项目(06GGYB965GX-030)
