兔颅脑损伤后内皮素与脑血流量的变化关系

The relationship between endothelin and cerebral blood flow after head injury of rabbits

目的：探讨兔颅脑损伤后内皮素（ET）与脑血流量（CBF）的变化关系。方法：利用BIM-Ⅱ型生物撞击机致伤中国大白兔额顶部制成的分级加速性颅脑损伤模型，分别采用放免法和氢清除法观察血、CSF、脑组织中ET与CBF的变化，并分析它们之间的相互关系。结果：伤后24h内，血浆、CSF、不同部位脑组织中ET水平呈与伤情程度相一致的升高。其中，CSF、脑组织中ET的变化趋势一致，血浆中ET的变化较之滞后。不同部位CBF呈与伤情程度一致的下降。各部CBF与相应组别CSF中及相应组别相应部位脑组织中ET的变化里显著负相关。结论：ET的异常分泌可能是颅脑损伤后脑缺血发生发展的原因之一。

Objective: To investigate the relationship between endothelin (ET) and cerebral blood flow (CBF) after head injury. Methods: Based on the model of the graded intensified head injury, developed by the BIM-Ⅱ bioimpactor striking the fronto-parital zone of the rabbits, the changes of ET in plasma, CSF,brain tissues of different regions, and CBF of the same brain regions were observed with RIA and hydrogen clearance methods respectively, and their relationship was analyzed. Results: During 24 h after injury, ET in plasma, CSF and brain tissues of different regions were increased consistently with injury seventy. The changing tendencies of ET in CSF and brain tissues were the same. The changes of CBF was negatively correlated with those of ET in CSF and brain tissue of the same region in the same group. Conclusion: The increase of ET may be one of the main causes to result in brain ischemia and its development after head injury.