测定神经降压素含量对急性颅脑损伤患者预后的评价

EVALUATION ON THE CONTENTS OF NT IN PLASMA AND CSF IN PATIENTS WITH ACUTE CRANIOCEREBRAL TRAUMA

目的：探讨急性颅脑损伤患者神经降压素含量变化及临床意义。方法：采用放免法动态测定51例急性颅脑损伤患者血浆及脑脊液神经降压素含量，以观察神经降压素水平在颅脑损伤组和正常对照组中的变化。结果：颅脑损伤患者急性期血浆及脑脊液神经降压素含量显著高于对照组，且与病情轻重程度明显相关。结论：神经降压素参与急性颅脑损伤后继发性病理生理损害；血浆或脑脊液神经降压素动态含量，可能成为判断急性颅脑损伤患者预后的重要因素。

Aim: Explore the evaluation on the contents of NT in plasma and CSF in patients with acute craniocerebral trauma.Methods: The NT levels in plasma and CSF of 51 patients with craniocerebral trauma and 20 normal people were determined dy namically by RIA. Results: NT level in plasma and CSF on the acute period in craniocerebral trauma group showed significantly higher than that in the contrast. These changes correlated with the severity of the injury. Conclusion: ①NT could cause second ary pathophysiologic injury after acute craniocerebral trauma. ②NT level in plasma and CSF after craniocerebral trauma might be important prognostic factor affecting the outcome in the patients with craniocerebral trauma.