支原体肺炎患儿自身免疫功能的检测及分析

Measurement and analysis of the autoimmunity functions in children with mycoplasma pneumonia

目的观察支原体肺炎患儿自身免疫功能的变化。方法将278例肺炎患儿分为支原体肺炎组135例、细菌性肺炎组143例,选取同期门诊体检正常小儿124例作为正常对照组,分别检测三组儿童的T细胞亚群、免疫球蛋白、补体C3、抗核抗体和循环免疫复合物。结果支原体肺炎组患儿细胞免疫功能处于低下状态,主要表现为CD4+T细胞及CD4+/CD8+比值降低,与正常对照组比较,差异有统计学意义(P<0.01);支原体肺炎组体液免疫功能明显异常,主要表现为IgM,IgA,IgE水平升高,C3,C4水平下降,血清免疫复合物、抗核抗体阳性比例较高,与细菌性肺炎组和正常对照组比较,差异有统计学意义(P<0.01)。结论支原体肺炎患儿容易有多种自身免疫功能的紊乱,可能与其多系统损伤有关。

Objective To observe the changes of autoinmmunity functions in children with mycoplasma pneumonia. Methods The T cell subgroup,immunoglobulin,complement,antinuclear antibody and circulating immune complex were detected in 135 children with mycoplasma pneumonia, 143 children with bacterial pneumonia and 124 normal children,respectively. Results The cellular immunity function was in a low state in children with mycoplasma pneumonia,mainly presented with a decreased percentage of CD4＋ T lymphocyte and a decreased ratio of CD4＋/CD8＋ （P〈0.01）. The humoral immune function was disordered in children with mycoplasma pneumonia, mainly presented with an increased level of IgM, IgA and IgE, an de- creased level of C3 and C4,as well as a higher positive percentage of ANA and CIC （P〈0.01）. Both of the differences had statistical significance. Conclusion children with mycoplasma pneumonia,which might There are multiple disorders of autoimmunity function in contribute to the multisystemie damage in children with mycoplasma pneumonia.