578例宫颈病变高危型HPV感染情况分析

The analysis on the infection of high risk type of HPV in cervical lesion of 578 cases

目的调查578例宫颈病变患者高危型人乳头状瘤病毒（human papilloma virus，HPV）感染的情况，探讨高危型HPV感染与宫颈病变的关系。方法采用第二代杂交捕获（the technique of hybrid capture，HC2）试验法检测578例宫颈病变患者高危型HPV感染情况，并与病理诊断进行分析。结果578例宫颈病变患者中，其中慢性宫颈炎176例，宫颈上皮内瘤变（cervical intra-epithelial neoplasia，CIN）患者402例，其中CINI 201例，CINⅡ 125例，CINⅢ 76例，其高危型HPV感染率分别为9.1％、60.2％、87.2％、93.4％，中高度CIN（指CINⅡ以上）的高危型HPV感染率明显高于低度CIN和慢性宫颈炎（P〈0.05）。高危型HPV的病毒载量与CIN的程度没有明显的相关性（P〉0.05）。结论高危型HPV感染与宫颈病变的发生、发展有关，并随病变程度的加重，感染率增高，高危型HPV的病毒载量与CIN的程度没有明显的相关性，故高危型HPV检测可用于宫颈癌和癌前病变的筛查及治疗后的随访。

Objective To study the relationship between the infection of high risk type of human papilloma virus（HPV） through the infection status of 578 cases with cervical lesion. Methods 578 cases with the infection of high risk type of HPV were examed by the second generation technique of hybrid capture（HC2） and the results were analyzed by pathologic diagnosis. Results There was 176 cases with chronic cervicitis, 201 eases with cervical intra-epithelial neoplasia（CIN） I , 125 cases with CIN Ⅱ, 76 cases with CIN Ⅲ and the rate of infection was 9.1%, 60.2%, 87.2%, 93.4% respectively. The infection rate of HPV of the cases with CIN Ⅱ and CIN Ⅲ was higher than that of the cases with CIN I and chronic cervicitis（P〈0.05）. There was no correlation between HPV viral load and different levels of CIN （ P 〉0.05）. Conclusion The examination of high risk type of HPV could be applied to screen the cervical cancer, cervical intra - epithelial neoplasia and also to follow - up the cases of post - treatmem.