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细胞周期末期促进复合物及其调节亚基Cdh1在缺血性脑损伤中的作用 被引量：1

Role of anaphase promoting complex and its regulatory subunit Cdhl in ischemic cerebral damage
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摘要 研究认为泛素-蛋白酶体系统与细胞周期成分在脑缺血后神经元凋亡及胶质细胞增殖活化中起着重要作用。细胞周期末期促进复合物（anaphase promoting complex，APc）及其调节亚基Cdh1是联系细胞内泛素．蛋白酶体系统与细胞周期成分的中间枢纽，是细胞周期进程调控的关键蛋白。现就APC-Cdh1在缺血性脑损伤中的作用作一综述。 Studies suggest that ubiquitin-proteasome system and cell cycle components play an important role in neuron apoptosis and glia cell proliferation after cerebral ischemia. Anaphase promoting complex （APC） and its regulatory subunit Cdh1 are intermedia to link intracellular ubiquitin-proteasome system and cell cycle components, and are the key proteins to regulate cell cycle process. This review summarizes the role of APC-Cdhl in neuron apoptosis and glia cell proliferation after cerebral ischemia.
作者 邱瑾 钱巍 张传汉
机构地区 华中科技大学附属同济医院麻醉科
出处 《国际麻醉学与复苏杂志》 CAS 2009年第4期360-363,共4页 International Journal of Anesthesiology and Resuscitation
基金 国家自然科学基金资助项目（30872452）
关键词 细胞周期末期促进复合物 脑缺血 神经元 胶质细胞 细胞周期蛋白 Anaphase promoting complex Ischemia Neurons Glia cells Cyclin
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献23

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同被引文献19

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国际麻醉学与复苏杂志
2009年 第4期

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