^18FDG PET在肿瘤放射治疗中的应用价值

Clinical application of ^18FDG PET in radiotherapeutic patients with cancer

目的对肿瘤患者放疗前及放疗后进行^18FDG PET显像随访，检验^18FDG PET在肿瘤放射治疗的应用价值。方法选择采用放疗的患者共15例，年龄（53±16．8）岁，（25—86）岁，男10例，女5例，接受放疗。肺癌6例，乳腺癌4例，食管癌3例，霍奇金淋巴瘤2例放疗前、中及后进行系列^18FDG PET全身检查，共59例次。FDG PET图像判断进行视觉分析和半定量分析。结果放疗前FDG PET检查13例，6例手术和／或化疗后有残存病灶的患者中2例发现了CT未发现的转移灶，临床据此改变了治疗计划。放疗中行FDG PET检查1例，结果显示与治疗前比较病灶缩小，摄取减低，提示肿瘤对射线敏感。放疗后随访15例中有6例出现复发或转移，其中2例为早期无症状者。结论本研究表明FDG PET全身检查在肿瘤患者放射治疗各个阶段都有很大应用价值。

Objective To evaluate the clinical effect of 2-[^18F]fluoro-2-deoxy-D-glueose positron emission tomography （^18FDG PET） in radiotherapeutic patients with cancer. Methods Fifteen patients with radiotherapy were selected, including ten males and five females in age of 53±16.8 years, between 25 and 86 years. Among them are six lung cancer patients, four breast cancer patients, three esophageal cancer patients, and two Hodgkin＇ s lymphoma patients. Serial PET imagings were performed prior to, in between, and post radiotherapy in a total of 59 PET scans. Visual and semiquantitative analyses were used to analyze the FDG PET images. Results 13 patients underwent PET imagings prior to radiotherapy treatment. Among 6 patients post operation and/or chemotherapy with residual tumor, metastases were detected in two patients with a negative CT result, leading to a change of their clinical treatment plan. One patient underwent FDG PET imaging during radiotherapy, and in comparison with the pretherapeutic study the patient＇ s foci became smaller and uptake lower which indicates a good response. Six out of the 15 cases were detected recurrence or metastases by posttherapeutic PET imaging. Two of the six recurrence/ metastases cases were shown asympomatic. Conclusion The study suggests FDG PET is a valuable modality to be used in each course of radiation therapy.