抗溃结复发方对UC模型大鼠结肠组织P-糖蛋白的影响

Influence of preventing recurrence formula for UC on P-gp level in colon tissue of ulcerative colitis in rats

目的探讨抗溃结复发方对溃疡性结肠炎(UC)模型大鼠结肠组织P-糖蛋白的影响。方法用三硝基苯磺酸(TNBS)复制实验性大鼠UC模型,将其随机分为模型组、抗溃结复发方组、畅美组,并设正常对照组。结果在治疗10 d时,两治疗组均可降低结肠组织P-糖蛋白水平,但两组之间相比差异无统计学意义(P>0.05);治疗30 d,抗溃结复发方组水平未见明显变化而畅美组水平升高,但两组之间相比差异无统计学意义(P>0.05);停药10 d,畅美组水平明显高于抗溃结复发方组(P<0.01)。结论抗溃结复发方与西药奥沙拉秦钠胶囊剂(畅美)比较,有效地抑制了P-糖蛋白的表达,从而发挥拮抗多药耐药的作用。

Objective To investigate influence of preventing recurrence formula for UC on P-gp level in colon tissue of ulcerative colitis model in rats. Methods UC model rats were duplicated with TNBS and randomly divided into model control group, west ern medicine group, Chinese medicine group and normal control group. Results After 10 days of treatment, P-gp level of colon organ in both treatment groups were increased significantly （P〉0.05）, but not significantly different （P〉0.05）; after 30 days, the level was increased in west ern medicine group but unchanged in Chinese medicine group （P 〉0.05）; and after 10 days discontinuation, the level in western medicine group was remarkably higher than that in Chinese medicine groups （P〈0.01）. Conclusion The preventing recurrence formula for UC is ef fective to inhibit the expression of P-gp in colon tissue, which can play a role to prevent drugs fast.