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通痹颗粒合甲氨喋呤对类风湿性关节炎患者VEGF的影响 被引量：4

Effects of Tongbi granules and methotrexate (MTX) on VEGF of rheumatoid arthritis (RA) patients
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摘要 目的探讨通痹颗粒合甲氨喋呤对类风湿性关节炎血管内皮生长因子(VEGF)的影响。方法将61例类风湿性关节炎患者随机分为治疗组(31例)和对照组(30例),治疗组予通痹颗粒和甲氨喋呤,对照组予甲氨喋呤,分别观察两组患者给药3个月前后VEGF变化情况。结果通痹颗粒联合甲氨喋呤能明显改善VEGF水平(P<0.05),疗效优于对照组,差异具有统计学意义(P<0.05)。结论通痹颗粒联合甲氨喋呤能降低血清VEGF的水平,其改善速度优于单用甲氨喋呤。 Objective To discuss the curative effect mechanisms of Tongbi granules（TBG） and MTX in treating RA on effects of TBG and methotrexate （MTX） on VEGF of patients with rheumatoid arthritis （RA）. Methods 61patients with RA were randomly derided into the testing group with TBG and MTX（31 cases） and the control group with MTX （30 cases）. Results TBG and MTX remarkably reduced the index levels of blood VEGF. Conclusion TBG combined MTX is more effective than MTX alone to reduce VEGF.
作者 贺选玲 王莘智 游柏稳 范伏元
机构地区 湖南中医药大学第一附属医院
出处 《湖南中医药大学学报》 CAS 2009年第4期53-55,共3页 Journal of Hunan University of Chinese Medicine
基金 湖南省自然科学基金资助项目(06JJ50041) 湖南省卫生厅中医药科研基金资助项目(6202) 湖南省重点学科中医内科学资助项目
关键词 通痹颗粒 甲氨喋呤 类风湿性关节炎 血管内皮生长因子 Tongbi granules methotrexate rheumatoid arthritis vascular endothelial growth factor
分类号 R593.22 [医药卫生—内科学]
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参考文献8

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二级参考文献21

  • 1Paleolog EM, Miotla JM. Rheumatoid arthritis:A target for antiangiogenic therapy[J]? Humana Press Inc, 2001,8(6):129-49.
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共引文献14

同被引文献61

引证文献4

二级引证文献27

湖南中医药大学学报
2009年 第4期

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