高强度可吸收内固定物治疗实验性骨折的形态计量学研究

Fixing the Experimental Fracture with Polyamide AbsorbableIntramedullary Nail: a Morphometric Study on the Healing

目的：应用聚酰胺可吸收髓内针治疗实验犬胫骨骨折愈合过程的骨形态计量学分析。方法：３６条杂种犬随机分为实验组与对照组。于左胫骨粗隆下３ｃｍ处横行截断胫骨，分别行可吸收髓内针和金属髓内针固定。术后１、２、４、８、１２周时分别采取骨痂标本，观察其组织学变化，计算骨形态计量学参数。结果：编织骨、矿化软骨等随固定术后时间的延长，含量逐渐下降，而板层骨含量逐渐增加，１２周时达高值，组织学上表现为以排列规则的板层骨为主；骨小梁体密度和平均骨小梁宽度两组一致；类骨质体密度、平均类骨质宽度、平均骨壁厚度和成骨细胞指数等，两组的测量值均接近或达到骨计量学参数的正常值。结论：可吸收髓内针固定长管状骨骨折与金属内固定比较。

Objective:This bone morphometric study was to evaluate the effect of polyamide absorbable intramedullary nail on the healing of experimental canine tibia fracture.Methods: 36 hyboid dogs were assigned randomly to experimental group and control group. The left tibia were transected 3 cm under the tubrosity and then given internal fixations with absorbable intramedullary nails in experimental group and metal ones in control group respectively. Callus samples were adopted at 1, 2, 4, 8, 12 weeks after the operation. The histological changes were observed and the bonemorphometric parameters calculated. Results: The content of woven bone and minalized cartilage decreased gradually after the operation, while the content of lamina bone increased gradually and reached the top value 12w afer the operation. Histology showed regularly arranged lamina bone. Vv and MTT. representing the maturity of bone trabeculla were the same in the both groups. The parameters reflecting the new bone formation reached, or nearly reached, to normal value of bone morphometry in both groups. Conclusions: Compared with metal internal fixation, the mode and time of healing after absorbable intramedullary nail fixation in long bone are the same. 