埃索美拉唑在内蒙古地区不同民族间胃食管反流病治疗中的应用

Efficacy of esomerphrazole in treatment of patients with gastroesophageal reflux disease between han and Inner Mongolia populations

目的观察埃索美拉唑治疗内蒙古地区不同民族胃食管反流病（GERD）患者的疗效。方法随机抽取2006年3月至2008年3月行胃镜检查及胃食管反流诊断问卷（RDQ）调查的120例汉族及120例蒙古族GERD患者，均给予埃索美拉唑20mg每日1次口服，共6周。治疗2、4、6周时，以RDQ进行评分，RE患者治疗6周复查胃镜，观察胃镜下食管炎症愈合情况。结果两组口服埃索美拉唑2周后临床有效率均大于50％，但第4、6周时，蒙古族组有效率明显低于汉族组。6周后蒙古族RE患者愈合率明显低于汉族组。结论因民族差异、饮食习惯的不同，导致埃索美拉唑治疗效果的不同，可通过延长用药时间、调整饮食习惯来取得更好的疗效。

Objective To assess the therapeutic effect of esomerphrazole in treating patients with gastroesophageal reflux disease （GRED） between Han and Inner Mongolia populations. Methods Those who underwent endoscopic examination and had reflux disease questionnaire （RDQ） 〉12 from March 2006 to March 2008 were selected. The patients were divided into Han group and Inner Mongolia group with 120 each. All patients were received esomerphrazole 20 mg daily for 6 weeks. The patients were evaluated by RDQ questionnaire at 2nd, 4th and 6th week, and were reexamined by gastroscopy at 6th week. Results After two weeks, effective rate of 50% was achieved in both groups, but it was higher in Han group than in Inner Mongolia group at 4th and 6th week. After 6 weeks, the curative rate of RE was higher in Han group than in Inner Mongolia group. Conclusion The different nations and habits result in the different efficacy of esomerphrazole, which may be improved by prolonging time of medication and changing habits.