埃索美拉唑治疗老年胃食管反流相关性哮喘69例临床观察

Clinical investigation on esomeprazole treatment of sixty-nine asthmatic patients with gastroesophageal reflux symptoms

目的观察埃索美拉唑抗反流治疗对胃食管反流相关性哮喘的疗效。方法69例胃食管反流相关性哮喘患者，在常规哮喘治疗基础上均给予每日1次每次埃索美拉唑40mg＋每日3次每次莫沙必利5mg抗反流控制治疗8周，之后每日1次每次埃索美拉唑20mg＋每日临睡前莫沙必利5mg维持治疗。按中华医学会呼吸病学分会哮喘组制定的支气管哮喘防治指南哮喘控制水平分级标准来观察疗效。随访2年。结果哮喘完全控制39例、部分控制25例，有效率92．8％。完全停用哮喘治疗药物42例、用量减半18例、继续用药9例。随访2年，哮喘完全控制58例、偶有发作11例，但发作次数减少、程度减轻。结论埃索美拉唑抗反流治疗胃食管反流相关性哮喘可明显改善患者症状，提高生活质量。

Objective To study the efficacy of esomeprazole in treatment of asthmatic patients with gastroesophageal reflux （GER） symptoms. Methods Sixty-nine asthmatic patients with GER symptoms were received esomeprazole 40 nag daily and mosapride 5 mg three times daily for 8 weeks. After that, esomeprazole 20 mg and mosapride 5 mg daily were prescribed to the patients for sustained therapy. The effect of asthma control was evaluated according to criteria for asthma control level made by Chinese Society of Respiratory Disease Asthma Group. All patients were followed up for 2 years. Results It was revealed that complete asthma control was achieved in 39 patients, well control in 25 patients and the total effective rate was 93%. Asthma control medication was stopped in 42 patients, dose reduced to 1/2 in 18 patients and continuous therapy in 9 patients. During 2 years follow-up, 58 patients were benefited from the treatment with complete asthma control and seldom attack of asthma was seen in 11 patients with reduced frequency and severity. Conclusion The symptoms of asthmatic patients with GER symptoms can be improved by esomeprazole, so that their quality of life are improved.