高龄初产妇及胎儿血清过氧化反应的研究

A Study of Maternal and Fetal Peroxidation in Elderly Primigravidea

目的分析孕妇年龄与孕妇及胎儿的过氧化反应的关系，研究高龄产妇并发症发病率升高的机理。方法将妊娠晚期妇女１６４例，根据年龄分成３组，第一组：小于３５周岁，７１例；第二组：大于或等于３５周岁但小于４０周岁，６３例；第三组：大于或等于４０周岁，３０例。所有病例均无其它高危因素。分别于分娩时抽取母血和脐血，检测超氧化物歧化酶（ＳＯＤ）和脂质过氧化物（ＬＰＯ）浓度。结果新生儿的Ａｐｇａｒ评分、胎儿体重以及羊水的质和量，３组之间比较，差异无显著性（Ｐ＞０．０５），剖宫产率随着年龄的增加明显增加；胎儿的ＳＯＤ浓度明显高于孕妇，ＬＰＯ明显地下降（Ｐ＜０．０５）；孕妇的年龄与其血清ＳＯＤ和ＬＰＯ浓度有明显的相关性（ｒ１＝－０．１５４７，Ｐ＜０．０５；ｒ２＝０．２２９９，Ｐ＜０．０１）；第二组和第三组孕妇ＬＰＯ浓度高于第一组（Ｐ＜０．０５），第三组孕妇ＳＯＤ浓度低于第一组（Ｐ＜０．０５）。结论孕妇的自由基含量和活性相对较高，而自由基的清除能力较弱，胎儿相反；

Objective To analyze the rlationship between the age of pregnant women and maternal and fetal peroxidation. Methods Pregnant 164 women in their third trimester were collected and divided into 3 groups according to maternal ages: in group 1, maternal age less than 35, n=71; group 2, maternal age 35～39, n=63; group 3, 40 or over, n=30. All the women had no other high risk factors. Maternal and umbilical blood samples were drawn during delivery, and the concentration of superoxide enzyme (SOD) and Lipid peroxidate produce (LPO) were determined. Results There were no significant differences in neonatal Apgar scores, birth weight, and the volume and quality of amniotic fluid among the 3 groups, but the cesarean scetion rate increased along with maternal age. The fetal SOD concentration was significantly higher than that in maternal serum, but the LPO level was lower. There was signficant correlation between maternal age and maternal serum SOD and LPO levels (r1=0.15, P<0.05; r2=0.229 9, P<0.01). The maternal LPO levels in group 2 and 3 were significantly higher than that in group1 (P<0.05), and the concentration of SOD in group 3 was significantly lower than that in group 1 (P<0.05). Conclusion The activity and concentration of free radicals were higher in mother than that in fetus, and the ability of antioxidation was lower in mother. The maternal age is associated with SOD and LPO levels during pregnancy.