红细胞膜脂质成分的变化与妊高征的关系

Relationship between Change of Eryrocyte Membrane Lipid Composition and Pregnancy Induced Hypertension

目的探讨红细胞膜脂质成分的变化与妊高征的关系。方法采用比色法、气相色谱法及全自动生化分析仪对２２例正常妊娠妇女，２４例健康未妊娠妇女，３６例妊高征患者进行红细胞膜磷脂、脂肪酸及胆固醇含量测定。结果（１）中、重度妊高征患者红细胞膜胆固醇含量及胆固醇／磷脂的比值均显著高于正常妊娠及健康未妊娠妇女（Ｐ＜０．０１）；（２）轻度妊高征患者红细胞膜胆固醇含量及胆固醇／磷脂比值与正常妊娠及健康未妊娠妇女比较，差异无显著性（Ｐ＞０．０５）。结论（１）红细胞膜胆固醇含量及胆固醇／磷脂比值的升高，可能是造成红细胞变形能力降低，微循环灌注障碍的主要原因之一，并参与了妊高征的病理生理过程；（２）妊高征患者红细胞膜脂质成分的变化与磷脂及脂肪酸含量无明显相关性。

Objective To study the cause of decreased erythrocyte deformability and its relation to pregnancy induced hypertension (PIH). Methods The cholesterol and phospholipid content of erythrocyte membrane in 24 nonpregnant heathy women, 22 normotensive pregnant women and 36 cases with PIH were determined using automatic biochemical analysor, Gas chromatography and modified colorimetric method. Results The cholesterol content and the cholesterol/phospholipid (C/P) ratio of the erythrocyte membrane were obviously higher in the group with moderate or severe PIH than that in the nonmotensive pregnancies (P<0.01). There was no significant difference between mild PIH group and the normotensive pregnant group (P>0.05). Conclusion The increase of cholesterol content and C/P ratio in the erythrocyte membrane might be involved in the pathophysiology of PIH. The alteration of cholesterol content in the erythrocyte membrane probaby reflected the disturbance of serum lipid metabolism.