柯萨奇B病毒感染对孕产妇及围生儿的影响

ANALYSIS OF INFLUENCE OF CBV INFECTIONON PREGNANT WOMEN AND PERINATAL

目的研究柯萨奇Ｂ病毒（ＣＢＶ）感染对孕产妇、围生儿的影响。方法应用间接免疫荧光法测定１６１例孕产妇及１８０例非孕育龄妇女血清ＣＢＶ特异性ＩｇＭ抗体。结果ＣＢＶ感染４６例，占１３．５％（４６／３４１），１６１例孕产妇采集了孕早期标本１０３例，孕中期８６例，孕晚期１５２例，ＣＢＶ阳性分别为７例（６．８％）、６例（７％）和２４例（１５．８％），１５２例脐血无１例阳性。１６１例早期新生儿无ＣＢＶ感染症状。结论孕产妇感染ＣＢＶ经胎盘垂直传播可能小，但检测ＣＢＶＩｇＭ对控制病源垂直传播和水平传播提供了证据。

おURPOSE To study the influence of Coaxsackie B virus (CBV) infection on pregnant women and perinatal.METHODS Special serum IgM antibody was detected with indirect immuo-fluorometry in 161 pregnant women and 180 non-pregnant women of childbearing age.RESULTS The incidence of infection in non-pregnant women was 5% (9/180). In 161 cases of diffe￣rent pregnant stages positive antibody was found 6.8% (7/103) in the early stage 7.0%(6/86) in the middle stage and 15.8% (24/152) in the late stage. No CBV antibody was detected in the blood samples from the 152 umbilical vein. No infectious symptom was revealed in 161 early newborn babies.CONCLUSIONS There is low possibility of CBV spread through the umbilical cord and determination of CBV IgM can provided evidence to control spread of this disease.