全子宫切除术后布托啡诺与曲马多静脉自控镇痛的比较

Comparison of intravenous analgesia with butorphanol and tramadol after hysterectomy

目的比较布托啡诺与曲马多术后静脉自控镇痛(PCIA)的效果。方法112例经腹全子宫切除全麻患者随机均分为两组:布托啡诺组术后使用布托啡诺0.2mg/kgPCIA;曲马多组使用曲马多10mg/kgPCIA。进行术后48h视觉模拟疼痛(VAS)评分、镇静和满意度评分,记录不良反应。结果布托啡诺组术后VAS评分和PCA过度使用者明显少于曲马多组[(1.6±0.5)vs.(3.4±1.1)和(5vs.11)](P<0.05),镇静和满意度评分明显高于曲马多组(P<0.01);布托啡诺组不良反应9例(16.1%),少于曲马多组的17例(30.4%)(P<0.05)。结论布托啡诺0.2mg/kg术后PCIA效果优于曲马多10mg/kg,不良反应发生率较低。

Objective To compare the outcomes of postoperative patien-controlled intravenous analgesia （PCIA） with butorphanol or tramadol. Methods One hundred and twelve patients underwent hysterectomy under general anesthesia were randomized to one of two groups with 56 cases each. The patients in group A were given PCIA with butorphanol 0.2 mg/kg and those in group B with tramadol 10 mg/kg. VAS and sedation scoring was performed within postoperative 48 hours. The side effects were recorded as well. Results The VAS scores and PCA numbers during analgesia were all less in group A than those in group B[（1.6±0. 5） vs. （3.4±1.1） and （5 vs. 11）] （P〈0. 05）. The scores of sedation and patient＇s satisfaction were significantly higher in group A than those in group B （P〈0. 05）. The side effects occurred in 9 cases（16.1%） in group A and in 17 cases（30. 4%） in group B（P〈0.05）. Conclusion Butorphanol 0.2 mg/kg is better than tramadol 10 mg/kg for PCIA with less side effects in the patients underwent hysterectomy under general anesthesia.