16岁以下青少年支气管哮喘的危险因素分析

Analysis of Risk Factors in Childhood Asthma under Aged 16 Years

收集了仅有１６岁以下青少年为子女的支气管哮喘核心家系的资料。２３０个家系资料的分析结果表明：１６岁以下的青少年中，男性患哮喘的危险性是女性的１．６２倍（Ｐ＜０．０１），饮用塘河水的人产生哮喘的危险性明显比饮用自来水的人高（ＯＲ＝１．６７，Ｐ＜０．０５）。父母的哮喘史是青少年最为突出的危险因素，使青少年患哮喘的危险性分别增加２．０６和２．７３倍，且均具有高度显著性意义。此家系分析也显示，母亲的哮喘史对子女产生哮喘的影响更大，约为父亲的两倍。青少年自身的气道高反应性和过敏体质也是青少年产生哮喘的危险因素之一，优势比分别为１．９２和２．０１（Ｐ＜０．０１）。本文揭示了遗传因素在哮喘发病过程中可能的重要作用。

The data of 230 asthma nuclear families that the offspring were under 16 years old.The results showed that the risk of male for asthma was 1 62 times higher than the female group( P <0 01).Drinking unclear water group was greater than drinking clear water group(OR=1 67, P <0 05).The asthma history of parents positive was a risk factor in the offspring asthma (OR=2 06,OR=2 73) compared with negative group there was statistics significant different.In this world the genetic factor play an important role in the childhood asthma.