口服转移因子对原发性肾病综合征患儿T细胞亚群的影响

Effects of Transfer Factor on T Lymphocyte Subset in Children with Primary Nephropathic or Nephrotic Syndrome

观察54例原发性肾病综合征患儿血T淋巴细胞亚群的变化，以及转移因子对血T淋巴细胞亚群的影响。分别在患儿急性期、口服转移因子后以及健康儿童抽血查CD3、CD4、CD8。发现急性期CD3、CD4、CD3／CD8下降，CD8上升，与正常对照组相比有显著差异；而口服转移因子后CD3、CD4、CD4／CD8上升，CD8下降，与正常对照组相比无差异。患儿急性期存在原发性肾病综合征T淋巴细胞功能紊乱，而使用转移因子有助于原发性肾病综合征疾病的缓解及预防复发。

To investigate the therapeutic effects of transfer factor on T-lymphocyte subset in children with primary nephrotic syndrome, authors analysed the numbers of CD3、CD4,CD8 in peripheral blood of healthy children and those sick children with primary nephrotic syndrome in acute stage be fore and after being treated with transfer factor respectively. In the acute stage of primary nephrotic syndrome, the number of CD,.CD' and ratio of CD4/CD8 were reduced, but CD8 was increased. There was significant defference to compare with healthy children.After treatment with transfer factor, the number of CD3,CD4 and ratio of CD4/CD8 were increased, but CD8 was reduced. There was no significant difference as compared with healthy children. Functional disorders of T-lymphocyte subset in the acute nephrotic stage of children were found but after the treatment of transfer factor, the disorders can be corrected.