一氧化氮与小儿系膜增殖性肾小球肾炎的相关研究

Correlative study of nitric oxide and mesangial prollferative glomendonephritts in childcrn

本研究探讨一氧化氮(NO)与小儿系膜增殖性肾小球肾炎(MsPGN)发病的关系。本组系膜增殖性肾小球肾炎28例,对照组25例,采用重氮化反应法测定MsPGN患者血清、尿中NO代谢产物水平。实验结果证明,MsPGN组血中NO水平与对照组无明显差异,但尿中NO水平明显低于对照组,MsPGN患者肾组织内产生NO能力处于抑制或缺陷状态。

The article try to search for the relationship of nitric oxide and mesangial proliferative glomerulonephritis (MsPGN). Serum and urine NO2- concentration, a metabolite of nitric oxide (NO), were measured in 28 patients with MsPGN and 25 control cases by Griess's method. No significant differences in serum NO2- concentration were found between the MsPGN and control groups. Urine NOf level in MsPGN group was markedly lower than that in control group. These results suggest that the production of NO in kidney is probably inhibited or defected in MsPGN patients.