分子标记物在肺腺癌预后评估中的意义

Molecular Marker As An Indicator in Presaging Prognosis of Human Lung Adenocarcinoma

对93例肺腺癌患者做分子流行病学研究,应用免疫组织化学染色方法,用Cox多因素回归模型,分析p21蛋白、p53蛋白、细胞增殖活性(PCNA)与预后的关系。结果表明:肺腺癌p21蛋白阳性的,预后不好,表达阳性的死亡危险性是阴性的2.08倍;p53蛋白与肺腺癌预后无关;PCNA阳性百分比高的,预后不好,肺腺癌PCNA阳性百分比50%以上的死亡危险性是肺腺癌PCNA阳性百分比20%以下的3.27倍。

The paper discusses 93 eases of human lung adenocarcinoma in terms of molecularepidemiology. The relationship between p21 protein and p53 protein and proliferationg cell nuclear antigen (PCNA) was analysed by immunohischemical methods. Prognosis by Cox model was used for prosnosis prediction of adenocarcinoma in human lung. Results showed that the prognosis of adenocarcinoma was poor when of p21 protein expression was positive and the relative ratio was 2.08. However, p53 protein expression was not related to the prognosis of adenocarcinoma. The bigher the positive rate of PCNA was, the poorer the prognosis of adenocarcinoma oppeared, with a ratio of 3.27.