^(99m)Tc-PPM肺肿瘤显像的初步评价

Clinical application study of ^(99m)Tcpeplomycin imaging in diagnosis of lung neoplasms

目的探索９９ｍＴｃ培普利欧霉素（ＰＰＭ）诊断肺癌的临床价值。方法用９９ｍＴｃＰＰＭ对３０例临床诊断为肺肿瘤病人进行ＳＰＥＣＴ显像。结果肺癌与肺良性病变对９９ｍＴｃＰＰＭ的摄取和储留差异均有显著性。对肺癌，以晚期摄取比值ｘ－ｓ为判断标准，其诊断灵敏度、特异性及准确度分别为８４％、８０％和８３％，以储留指数ｘ－ｓ为阈值，则分别为８８％、１００％和９０％。肺癌不同组织学类型之间差异无显著性（Ｐ＞００５）。９９ｍＴｃＰＰＭ诊断肺癌与病理学检查结果的符合率大于ＣＴ和ＭＲＩ。

Purpose To evaluate the clinical value of ^(99m)Tcpeplomycin (PPM) imaging for the diagnosis of lung neoplasms Methods The SPECT imaging was performed on 30 patients with pulmonary lesions SPECT data were acquired 30 minutes and 3 hours after the injection of 740～1110MBq PPM The early ratio, delayed ratio and retention index (RI) was calculated Results The uptake ratio and RI of ^(99m)TcPPM were different between malignant and benign lesions When the delayed ratio (-s) was 118 as threshold, the sensitivity, specificity and overall accuracy of ^(99m)TcPPM imaging for the malignant lesion was 84%, 80% and 83%, respectively, and there was no significant difference in different histological entities of the lung carcinoma (P>0.05) The diagnosis concordance of ^(99m)TcPPM with the histologically diagnosed lung cancer was higher than that of X-CT and MRI Conclusions ^(99m)TcPPM is a good imaging agent and was useful in differentiating malignant lung neoplasms from bengin ones