胃肠道粘膜相关淋巴组织型淋巴瘤的研究

MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA OF GASTROINTESTINAL TRACT

目的：研究胃肠ＭＡＬＴ淋巴瘤的临床病理、免疫表型及与幽门螺旋杆菌的关系。方法：应用免疫组织化学进行免疫分型，对ＭＡＬＴ淋巴瘤和淋巴细胞反应性增生进行鉴别，用Ｇｉｅｍｓａ染色显示幽门螺旋杆菌，对患者进行随访。结果：本瘤均为单克隆Ｂ细胞起源，６８．１７％胃ＭＡＬＴ淋巴瘤，４６．１５％小肠ＭＡＬＴ淋巴瘤与幽门螺旋杆菌感染有关，与同期淋巴结内的非何杰金氏淋巴瘤比较预后较好，差异有显著性（Ｐ＜０．００１）。结论：因本瘤与幽门螺旋杆菌的感染有关，临床在化疗同时应加用抗生素，早期病变是否可单独使用抗生素，尚需进一步研究。

Purpose:To study the clinicopathology,immunotype of gastrointestinal mucosa associated lymphoid tissue (MALT) lymphoma and the relationship between gastroinstestinal MALT lymphoma and Helicobacter pylori (Hp).Method:An immunohistochemical staining was used to detect the immunotype and distinguish MALTtype lymphoma from reactivated lympho node.Giemsa staining was used to detect Hp.Result:All tumor cells are of monoclonal B cell origin.68.17% gastric and 46.15% small instestinal MALTtype lymphoma were infected by Helicobacter pylori.The biological behaviour of gastroinstestinal MALT lymphoma was significantly better than that of lympho nodes in the same stage.Conclusion:Our result suggests that because the lymphoma is involved in Hp infection,antibiotics must be used concurrently with chemotherapy clinically.It needs to do further research whether the early gastrointestinal MALT lymphoma can be cured with antibiotics alone.