贲门癌细胞多向分化的临床意义

Clinical Significance of Multidirectional Differentiation of Cells Gastric Cardiac Carcinoma

目的：探讨贲门癌细胞生物学行为及其临床意义。方法：应用Ｓ－Ｐ免疫组织化学方法，应用Ｖｉｍ、ＣＨＧ、ＨＣＧ３种抗体对６２例贲门癌进行标记。结果：ＣＨＧ抗体表达１２例，ＨＣＧ表达３２例，Ｖｉｍ表达３３例，ＣＨＧ－Ｖｉｍ共同表达１２例，ＨＣＧ－Ｖｉｍ共同表达１９例，ＣＨＧ－ＨＣＧ共同表达９例，ＨＣＧ－Ｖｉｍ－ＣＨＧ共同表达８例。其中Ｖｉｍ、ＨＣＧ表达的肿瘤６０％以上出现在低分化癌细胞中。结论：贲门癌具有多向分化的特征，伴有向间叶、滋养叶分化的肿瘤大多数分化低并与临床预后有一定关系。对认识贲门癌生物学行为，探讨其预后及依肿瘤向不同组织分化采用药物治疗有指导意义。

Objective:This paper was to study the biological behavior of cells from cardiac cancer and its clinical implications.Methods: Sixty-two specimens from gastric cardiac carcinoma were marked by three kinds of antibodies Vim,HCG,and CHG. We observed the positive espression of cells by immunohistochemical technique(S P).[WT5”HZ〗Results:[WT5”BZ]Positive expression was present in 33 specimens for Vim,in 32 for HCG,and in 14 for CHG. Co expression was present in 19 cases for Vim HCG,in 9 for HCG CHG,in 12 for Vim CHG,and in 8 for Vim CHG HCG. Conclusions:Cells in cardiac carcinoma exerted a function of multidirectional differentiation,which might guide the physicians to select more specific drugs. Most poorly differentiated cells were in positive expression of HCG Vim,which was related with prognosis.