摘要
用高脂饲料喂养Wistar大鼠20天,造成大鼠高血脂症模型,然后分别灌胃(ig)给予颐正活脉丸4.3g/kg,以临床降脂药物绞股蓝总苷片0.03g/kg为阳性对照。灌胃实验第20天后取血清测定总胆固醇(TC)和甘油三酯(TG)、高密度脂蛋白(HDL-C)和低密度脂蛋白(LDL-C),结果颐正活脉丸能降低高血脂症模型大鼠血清中TC、TG和LDL-C含量,升高高血脂症模型大鼠血清中HDL-C含量,效果与阳性对照组绞股蓝总苷相当,与高脂对照组比较,经t检验,均有显著性差异。表明颐正活脉丸具有明显的降血脂作用。
Some Wistar rat medels with hyperlipidemia were made by high fat feeding for 20 days. Then they were respectively given stomach peffusion with YiZhenghuomai Wan（4. 3g/kg）, compared with those in the positive control group treated by the clinical lipid-lowering medicine gypenoside tablets （0. 03g/kg）. After 20 days the rats＇serum was taken for determination of TC ,TG,HDL-C and LDL-C. The result showed the medicine could lower the content of TC ,TG and LDL-C and increase the content of HDL-C in the hyperlipidemia rat models, whose effect was equivalent to that of positive control group of gypenoside tablets. There was a significant difference in comparison of high lipid group and proved by t test. The experiment indicated YiZhenghuomai Wan has marked lipid-lowering effect.
出处
《中华中医药学刊》
CAS
2009年第8期1696-1697,共2页
Chinese Archives of Traditional Chinese Medicine
基金
河南省教育厅自然科学基金研究项目(2008A360029)
