布渣叶水提物镇痛药效学的实验研究

Experinental Study On the Pharmacodynamics in Analgesic of Water-extract of Microcos Paniculata

目的:研究布渣叶水提物的镇痛作用,为临床用药提供科学的理论依据。方法:采用小鼠热板法和冰醋酸致小鼠扭体反应,观察布渣叶水提物高剂量组(23.4g/kg)、中剂量组(11.7g/kg)、低剂量组(5.85g/kg)对疼痛的抑制作用,并设空白对照组比较。结果:布渣叶水提物各剂量组均能抑制小鼠因热刺激所引起的疼痛反应;而高、低剂量组能抑制小鼠因化学刺激所引起的疼痛反应,与空白对照组比较差异有显著性。结论:布渣叶水提物具有较好的镇痛作用。

Objective：To investigate the analgesic action of Water-extract of Microcos paniculata, and to provide scientific experiment evidence for clinical applications. Methods ： The analgesic effect was observed by using pain models induced by heat plate and acetic acid - induced writhing at the same time, different doses were used and compared with the control group. Results ： All the three doses of Microcos paniculata significantly reduced the the aching reaction induced by heat ;and high and low doses of Microcos paniculata significantly reduced the the aching reaction induced by acetic acid. Conclusion：Microcos paniculata have significant analgesic effect.