摘要
目的研究心力衰竭患者外周血sCD14水平的变化特点,探讨sCD14水平与慢性心力衰竭患者心功能及单核细胞的相关性。方法选取慢性心力衰竭患者126例,入院次日清晨抽取静脉血,并以50例健康人作为对照。根据NYHA分级将慢性心力衰竭患者按心功能I、II、III、IV四个等级分为四组。ELISA法测定血清中的sCD14含量,并计算外周血中单核细胞的数量及百分比。结果心功能I、II级慢性心力衰竭患者外周血清中sCD14水平、单核细胞数量及百分比与健康对照组相比无明显差异(P>0.05),心功能III、IV级慢性心力衰竭患者外周血中sCD14水平、单核细胞数量及百分比与健康对照组及心功能I、II级患者相比均显著增加(P<0.05);心衰患者sCD14水平与心衰分级、单核细胞数量及百分比均呈显著正相关(r=0.731,P=0.011;r=0.872,P=0.013;r=0.769,P=0.027)。结论慢性心力衰竭患者外周血中的sCD14水平随着心功能加重而逐渐增高。
Objective To investigate the levels of soulable-CD14（sCD14） in peripheral blood in patients with chronic heart failure and the correlation of the level of sCD14 with the quantities of peripheral blood mononuclear cells. Methods 126 patients with chronic heart failure were assigned four groups according to NYHA（NYHA Ⅰ group, NYHA Ⅱ group, NYHA Ⅲ group and NYHA Ⅳ group）,and 50 healthy volunteers were enrolled as control group. The levels of sCD14 in peripheral blood were measured by ELISA and calculated the the quantities of peripheral blood mononuclear cells. Results There were no difference of the levels of sCD14 and the quantities of mononuclear cells in NYHA Ⅰ group and NYHA Ⅱ group compared with control group（P 〉 0.05）. The levels of sCD 14 and the quantities of mononuclear cells in NYHA Ⅲ group and NYHA Ⅳ group were significantly higher than those in NYHA Ⅰ group,NYHA Ⅱ group and control group（P〈 0.05 ）. The levels of sCD14 were markedly positively correlated with heart function classification and the quantities of mononuclear cells respectively（r = 0.731, P = 0.011 ; r = 0.872, P = 0.013 ; r = 0.769, P = 0.027 ）. Conclusion The levels of sCD14 were significantly increased with the increasing of severity degree of heart function.
出处
《中国现代医生》
2009年第23期17-18,35,共3页
China Modern Doctor
