胰腺癌P^(16)蛋白的表达及其临床意义

Expression and significance of P^(16) protein in human pancreative carcinoma

应用免疫组织化学LSAB法检测P16蛋白在胰腺癌中的表达。结果显示，47例胰腺癌P16蛋白表达阳性率为55．3％（26／47）；其阳性率与患者性别、年龄、肿瘤大小，病理学类型及组织学分级无关；而与胰腺癌临床分期和患者1年生存率明显相关（P<0．05）。表明P16基因缺失或突变在胰腺癌发生发展的后期发挥重要作用；P16蛋白低表达者预后差。因此P16蛋白可作为胰腺癌的分子生物学标志。

The Affiliated Hospital of Qingdao Medical College, Qingdao 266003The expression of P16 protein in 47 pancreative carcinoma was studied immunohistochemically, 26 cases showed positive staining of P16 protein (55. 3%). These immunoreativities were most common in the cytopalsm of tumor cells. There was nosignificant relationship between the expression of P16 protein and tumor sizehistopathologic classification histologic grading or patient's sex and age. However, inverse relationships were observed between P16 protein expression and clinical stage(TNM) (P2 = 5. 43, P<O. 05). Espression of p16protein was Positively associated withpost-operative survival (l year) and the relationship was significant (P= 0. 043, P<0. 05 ). These results suggset that p16gene play an important role n antimetastasis ofpancreative carcinoma, and mayserve as a indictor to predict the prognosis of patients.