结直肠癌BNIP3基因表达及临床研究进展
摘要
BNIP3(bcl-2/E1B 19kDa interacting protein3)基因是BCL-2基因家族成员之一,属抑癌基因,其正常功能的发挥对维持机体内环境稳定、更新衰老细胞、清除导致疾病的异形细胞和引起肿瘤的畸变细胞有重要意义,为机体正常生长发育及新陈代谢所必不可少。
出处
《肿瘤预防与治疗》
2009年第3期320-323,共4页
Journal of Cancer Control And Treatment
参考文献36
-
1Graham RM, Thompson JW, Wei J, et al. Regulation of Bnip3 death pathways by calcium, phosphorylation, and hypoxia-reoxygenation[ J]. Antioxid Redox Signal ,2007,9 (9) : 1309-1315.
-
2Love S. Apoptosis and brain isehemia[ J]. Prog Neuropsychophermacol Biol Psychiatrg, 2003, 27(2) : 267-282.
-
3Burlacu A. Regulation of apoptosis by Bcl-2 family protein[ J]. Cell Mol Med, 2003, 7(3) : 249-257.
-
4Reed JC. Mechanisms ofapoptosis[J]. Am J Pathol, 2000, 157 (5) : 1415-1430.
-
5Burton TR, Henson ES, Baijal P, et al. The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia[ J ]. International Journal of Cancer, 2006, 118 : 1660 - 1669.
-
6Howard R, Mellor AL, Harris. The role of the hy-poxia-inducible BH3-only protein BNIP3 and BNIP3L in cancer[ J]. Cancer Metastasis Rev,2007,26(3-4) :553-566.
-
7Sulistijo ES, Jaszewski TM, MacKenzie KR. Sequence-specific dimefization of the transmembrane domain of the BH3-only protein BNIP3 in membranes and detergent [ J ]. Biol Chem, 2003,278 (51) :51950-51956.
-
8Guo K, Searfess G, Krolikowski D, et al. Hypoxia induces the expression of the pro-apoptotic gene BNIP3[J]. Cell Death Differ, 2001,8(4) : 367-376.
-
9Burlacu A. Regulation of apoptosis by Bcl- 2 family protein [ J ]. Cell Mol Med, 2003, 7(3) : 249-257.
-
10Schindler CK, Shinoda S, Simon RP, et al. Subcellular distribution of Bcl-2 family protein and 14-3-3 within the hippocampus during seizure induced neuronal death in the rat [ J ]. Neurosci Lett, 2004, 356(3): 163-166.
二级参考文献6
-
1Guo K,Searfoss G,Krolikowski D,et al.Hypoxia induces the expression of the pro-apoptotic gene BNIP3[J].Cell Death Differ,2001;8(4):367-76.
-
2Manka D,Spider Z,Millhom DE. Bcl-2/Adenovirus EIB 19 kDa interacting protein-3 knockdown enables growth of breast cancer metastases in the lung,liver and bone[J].Cancer Res,2005;65(24):11689-93.
-
3Bruick RK. Expression of the gene encording the proapoptotic BNIP3 propein is induced by hypoxia[J].Pro Natl Acad Sci USA,2000;97(16):9082-7.
-
4Burton TR,Henson ES,Baijal P,et al.The procell death Bcl-2 family member,implications for glioblastoma multiforme tumor cell survival under hypoxia[J].Int J Cancer,2006;118(7):1660-9.
-
5Sowter HM,Ferguson M,Pym C,et al.Expression of the cell death genes BNIP3 and NIX in ductal carcinoma in suit of the breast,correlation of BNIP3 levels with necrosis and grade[J].Cancer Res,2005,65(24):11689-93.
-
6Giatromanolaki A,Koukourakis MI,Sowter HM,et al.BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer[J].Clin Cancer Res,2004,10(16):5566-71.
共引文献2
-
1罗靖,程宏伟,冯春国,徐培坤,肖瑾,李严.BNIP3在人髓母细胞瘤中的表达及其与预后的关系[J].安徽医学,2010,31(6):553-555.
-
2勾晶,孙佳,甄永生.IL-10、Fascin及SPFR1与喉部鳞状细胞癌临床特征关系的研究[J].中国处方药,2014,12(5):105-106.
-
1谷梅,潘慧清.汗腺癌1例[J].岭南皮肤性病科杂志,2003,10(3):206-207. 被引量:1
-
2李潇.衰老细胞激发附近细胞生长肿瘤[J].科技文萃,2002(4):102-103.
-
3任杰,黄孝永,代永霞,李歌,陈思远.腋窝乳房外Paget病[J].临床皮肤科杂志,2016,45(1):29-31. 被引量:2
-
4赵则祥.细胞凋亡与癌[J].生物学通报,2003,38(5):16-17. 被引量:1
-
5抑制能量代谢可以选择性地破坏休眠癌细胞[J].微循环学杂志,2013,23(4):31-31.
-
6姬峻芳,詹启敏,吴旻.Bcl-2与P53的相互作用[J].医学分子生物学杂志,2005,2(2):102-104. 被引量:9
-
7马丽,赵海燕.老年食管癌术后护理[J].实用医技杂志,2004,11(06A):952-952. 被引量:11
-
8詹平,毛熙光.Fas/FasL与宫颈癌关系的研究进展[J].国外医学(计划生育分册),2005,24(6):293-296. 被引量:2
-
9王庆庆,盛陈毅,陈锦鹏,倪启超.Ski相关蛋白在乳腺癌中的表达及其预后分析[J].南通大学学报(医学版),2014,34(6):485-488.
-
10王宇,李伟红,方丹.肝癌切除术的术中护理及手术相关因素观察[J].护士进修杂志,2001,16(3):196-197. 被引量:4