上皮膜抗原与膀胱肿瘤生物学行为关系的研究

Epithelial membrance antigen in bladder tumors: correlation with biological behavior

为探讨上皮膜抗原（EMA）免疫标记与膀胱肿瘤生物学行为的关系，采用LSAB免疫组织化学技术对54例膀胱肿瘤石蜡切片标本进行研究。研究发现随着肿瘤分级和分期的增加，EMA阳性细胞率明显减低（P＜0．01）。EMA的标记表达率在初发与复发及单发与多发肿瘤之间有极显著性差异（均P＜0．01）。尽管EMA在男性和＞50岁患者中表达率较低，但与相应女性和≤50岁患者相比无显著性差异（P＞0．05）。研究表明，EMA与膀胱肿瘤生物学行为关系极密切，可作为判断膀胱肿瘤恶性程度和预后的重要标记物。

To confirm the value of the EMA labelling index in relation to biological behavior parameters of bladder tumors, 54 cases of bladder tumors were investigated using an LSAB immunohistochemical method in paraffin sections it was found that the frequency of EMA-positive cells decreased with increase of the tumor grade and stage(P<0.01). There were sighficant difference in EMA labelling index between initial tumors and recurrent tumors (P <0. 01 ),and between single tumors and multiple tumors (P<0. 01). Though the expression of EMA in male and in >50 years old was lower than in female and in≤50 years old,these did not reach statistic significance (P>0.05). The results indicated that EMA was closely related to biological behavior of bladder tumors. It was essential marker for judging the malignancy and prognosis of bladder tumor.