帕金森病非痴呆和痴呆患者载脂蛋白E基因型分析

Analysis of apolipoprotein E in Parkinson′s disease with and without dementia

目的探讨帕金森病（ＰＤ）和帕金森病痴呆（ＰＤＤ）患者的载脂蛋白Ｅ基因频率及表型分布与ＰＤＤ发病的关系。方法对ＰＤ组（３６例）和ＰＤＤ组（３２例）的临床资料进行回顾性分析，并设正常非痴呆对照组（６０例），比较三组载脂蛋白Ｅ的基因频率及表型的分布。结果ＰＤ、ＰＤＤ和正常非痴呆对照组都以ＡｐｏＥε３基因频率最常见，约占９３％，ＡｐｏＥε４和ε２基因频率三组相比差异无显著意义。三组ＡｐｏＥ基因表型分析发现Ｅ３／３型最为常见，含Ｅ４或Ｅ２基因频率表型差异无显著意义。结论ＰＤＤ发病与ＡｐｏＥε４或ε２基因频率无关，推论ＰＤＤ与ＡＤ发病机制不同。

Objectives To study the genotypes vs phenotypes of apolipoprotein E(ApoE) between the Parkinson′s disease without dementia (PD) group and with dementia (PDD) group. Methods The clinical data of the Parkinson′s disease without PD and with PDD dementia groups (36 cases and 32 cases) and the non dementia control group (60 cases) were respectively and comparally studied. The distribution of the genotypes vs phenotypes of ApoE in the three groups were also identified. Results The genotype of ApoE ε3 was more predominant (accounting for 93.0%) in PD. PDD and non dementia centrol groups without the difference of the genotype of ε4 and ε2. The phenotype of ApoE 3/3 was more common in PD, PDD and non dementia control groups without the difference of the phenotypes including E4 and E2. Conclusion There was no correlationship between the PDD and ApoE ε4 and ε2, suggesting that the pathogenesis of PDD was quite different from that of AD.