摘要
目的探讨帕金森病(PD)和帕金森病痴呆(PDD)患者的载脂蛋白E基因频率及表型分布与PDD发病的关系。方法对PD组(36例)和PDD组(32例)的临床资料进行回顾性分析,并设正常非痴呆对照组(60例),比较三组载脂蛋白E的基因频率及表型的分布。结果PD、PDD和正常非痴呆对照组都以ApoEε3基因频率最常见,约占93%,ApoEε4和ε2基因频率三组相比差异无显著意义。三组ApoE基因表型分析发现E3/3型最为常见,含E4或E2基因频率表型差异无显著意义。结论PDD发病与ApoEε4或ε2基因频率无关,推论PDD与AD发病机制不同。
Objectives To study the genotypes vs phenotypes of apolipoprotein E(ApoE) between the Parkinson′s disease without dementia (PD) group and with dementia (PDD) group. Methods The clinical data of the Parkinson′s disease without PD and with PDD dementia groups (36 cases and 32 cases) and the non dementia control group (60 cases) were respectively and comparally studied. The distribution of the genotypes vs phenotypes of ApoE in the three groups were also identified. Results The genotype of ApoE ε3 was more predominant (accounting for 93.0%) in PD. PDD and non dementia centrol groups without the difference of the genotype of ε4 and ε2. The phenotype of ApoE 3/3 was more common in PD, PDD and non dementia control groups without the difference of the phenotypes including E4 and E2. Conclusion There was no correlationship between the PDD and ApoE ε4 and ε2, suggesting that the pathogenesis of PDD was quite different from that of AD.
出处
《中华神经科杂志》
CAS
CSCD
1998年第3期149-151,共3页
Chinese Journal of Neurology