缺血性中风患者血小板膜磷脂、膜流动性与血小板功能的相关性研究

The relafionship of Platelet Membrane Phospholipids and Platelet Function with Ischemic Stroke

本文对４９例缺血性中风患者及３７例健康人的血小板膜磷脂、膜流动性及血小板功能进行了研究分析．结果发现：与对照组相比，缺血性中风志者血小板膜流动性及著降低．神经鞘磷胆（ＳＭ）显著升高，磷脂酰丝氨酸（ＰＳ）磷脂酰乙醇胺（ＰＥ）显著降低，磷脂酰胆碱（ＰＣ）有下降趋势，但无统计学意义．血小板聚集功能明显增强．相关分析发现脑梗塞患者血小板膜流动性与血小板膜脂ＳＭ成负相关；与膜ＰＣ成正相关，与血小板聚集功能呈负相关，提示血小板膜磷脂的变化对血小板膜流动性产生了的影响，导致血小板聚集功能的变化，最终诱发缺血性脑中风．

Platelet membrane individual phospholipid classes, Platelet membrane fluidity and platelet function were measured in 49 patients with ischemic stroke and 37 normal controls. We found that platelet membrane fluidity was decreased, Sphingomyelin (SM) was obviously increased, PS(phosphatidylserine)、PE (phosphatidylethanolamine) were decreased; platelet aggregation function was significiantly increased. In the mean time we also found that in patients membrane fluidity had nagtive relationship with SM, positive relationship with PC, and had nagtive relationship with platelet aggregation function. The results suggest that the changes of membrane phospholipids affect the membrane fluidity, and result in changes of platelet aggregation function.