脑梗塞患者血浆、脑脊液内皮素、心钠素含量的变化及其临床意义

Changes and clinical significance of ETI and ANP in plasma and CSF in the patients with cerebral infarction

目的：探讨ＥＴＩ和ＡＮＰ两种神经肽在急性脑梗塞中可能的发病机制及其相关关系。方法：运用放射免疫方法测定了４４例急性脑梗塞患者血浆、脑脊液ＥＴＩ和ＡＮＰ含量。结果：ＥＴＩ是反映脑梗塞病情严重程度的指标之一；结论：ＣＳＦＡＮＰ水平的变化可能是机体对抗脑水肿发生的一种应激保护反应；缺氧是刺激ＥＴＩ合成和释放的一个敏感因素，脑组织缺氧所致脑血管舒缩物质失衡可能是局灶性脑血管麻痹的原因之一。

To investigate the possible roles of two neuropeptides, endothelin1(ETI) and atrial natriuretic polypeptide(ANP) in the pathogenesis of cerebral infarction and their relationships, ETI and ANP concentration in plasma/CSF in 44 patients with cerebral infarction(patients group) and control group were measured by radioimmunoassay. The results indicated that ETI was one of indices reflecting the degree of neurological injury and that the changes of ANP levels in CSF may be a stress neuroprofective effect against ischemic brain edema and that hypoxia was a sensitive factor suggested tha systhesis and release of ETI,and that the imbalance between vasodilators and vasconstrictors in brain resulted from hypoxia may contribute to the local cerebrovascular paralysis.