Carboplatin致灰鼠内毛细胞损害的扫描电镜观察

The Scannig Electron Microscopic Study on Carboplatin-Induced Damage to Inner Hair Cells of Chinchilla Cochlea

本文应用扫描电镜观察了Carboplatin耳中毒引起的内毛细胞表面亚显微结构的改变。发现用药后仅1天，在内毛细胞表面即开始出现球状物，同时伴有个别内毛细胞坏死，注药后3天，大多数内毛细胞的纤毛发生散乱。注药后30天，坏死的内毛细胞处为支持细胞所替代，残存的内毛细胞表面结构可以恢复正常。

Scanning electron microscopic analyses were performed on carboplatin - treated chinchilla cochlea in the present study. The results showed a progressive deterioration of inner hair cells, i. e,cytoplasm protrusion was evidenced one day post treatment followed by disarray of the cilia in most inner hair cells two days later. Thirty days after the drug administration, the survival inner hair cells showed a normal appearance whereas some inner hair cells died and were replaced by supporting cells.