氟比洛芬酯复合布托啡诺用于肝癌切除术后静脉镇痛观察

Application of Flurbiprofen Combined with Butorphanol in Postoperative Intravenous Analgesia in Hepatoma Resection

目的:评价氟比洛芬酯复合布托啡诺用于肝癌切除术后静脉镇痛的临床效果及安全性,并与常用的吗啡复合罗哌卡因硬膜外镇痛比较。方法:60例择期肝癌切除术患者,随机分为两组:实验组用氟比洛芬酯复合布托啡诺静脉镇痛,对照组用吗啡复合罗哌卡因硬膜外镇痛。记录术中出血量、术毕苏醒时间、术后镇痛视觉模拟评分(VA S)、首次排气时间、住院时间、镇静评分及不良反应。结果:两组术后VA S评分、术中出血量、术后首次排气时间、住院时间、及镇静评分无统计学差异(P>0.05)。实验组术毕苏醒时间延长10.3 m in,但术后不良反应少于对照组(P<0.01)。结论:氟比洛芬酯复合布托啡诺静脉镇痛可作为肝癌切除术可供选择的,安全有效的术后镇痛方法。

Objective：To evaluate the clinical efficacy and safety of flurbiprofen combined butorphanol in postoperative intravenous analgesia in hepatoma resection,and to compare with commonly used morphine combined with ropivacaine epiduaral analgesia. Methods ：Sixty patients undergoing elective hepatoma resection were randomly divided into two groups：experiment group given flurbiprofen combined with butorphanol intravenous analgesia,and control group given morphine combined with ropivacaine epiduaral analgesia. Intraoperative blood loss, time to recovery from anesthesia ,postoperative analgesia visual analogue scale （VAS）,time to first flatus, postoperative length of stay,sedation scores and adverse effects were recorded. Results ：No statistical difference in the VAS, intraoperative blood loss, time to first flatus, postoperative length of stay, sedation scores were found between the two groups （P2〉0. 05）. Time to recovery from anesthesia of experiment group was longer by 10. 3 rain,however adverse events was less in comparison with control group（P〈0.01）. Conclusions ：Flurbiprofen combined butorphanol intravenous analgesia offers an alternative, safe and effective postoperative analgesia method for hepatoma resection.